A Comprehensive Guide to Enzyme Supplements: Evaluating Costs, Ingredients, and Efficacy


In the quest for optimal health, enzyme supplements have become a popular choice for individuals seeking to improve digestion and address various neurological conditions. This detailed guide delves into the intricacies of selecting and evaluating enzyme supplements, ensuring you make an informed decision tailored to your health goals. With a focus on cost-effectiveness, ingredient quality, and product research, this guide is your ally in navigating the complex world of enzyme supplementation.

Step 4: Evaluating Enzyme Supplement Costs

When considering enzyme supplements, it’s crucial to assess the financial aspect of your choice. Begin by determining the cost per capsule, which involves calculating the total cost of the bottle, including any discounts, taxes, and shipping fees. Divide this total by the number of capsules to find the cost per individual dose.

Activity Per Capsule: A Key Metric

Beyond cost, the activity per capsule is a vital comparison metric. Look for products that specify enzyme activity in recognized units rather than weight, as weight alone does not indicate enzyme efficacy. For instance, 100 mg of an enzyme with no activity is useless, whereas the same weight could represent a wide range of activity levels. Ensure you’re comparing identical units, or find a conversion factor if necessary.

Understanding Enzyme Standards

The U.S. Pharmacopeia (USP) has established standards for pancreatic enzymes, which can be used to compare plant- and microbial-derived enzyme supplements. The USP standard, denoted as ‘X’, includes:

  • 25 USP units of amylase
  • 2 USP units of lipase
  • 25 USP units of proteolytic enzymes

A product with 5X pancreatic enzymes would contain five times these amounts. However, there is no direct conversion between USP units and Food Chemical Codex (FCC) units due to differences in source and production methods.

Dosage Considerations

It’s also important to consider the recommended dosage. Some products may require only one capsule per meal, while others suggest four or more, significantly impacting cost and convenience. Additionally, enzyme powders are less common due to their susceptibility to activity loss upon exposure to air.

Capsule Counts and Serving Sizes

Always verify the number of capsules that constitute a serving, as this can affect perceived value. Marketing strategies may lead consumers to believe they are receiving more activity per serving than is actually provided. Capsule counts typically come in increments of 60, 90, or 120.

Cost Comparison Example

Here’s an illustrative cost comparison:

  • Bio88+ (Plus): $40 for a 45-day supply, equating to $0.40 per serving.
  • Company A: A total of $0.455 using two capsules for all food groups.
  • Company B: A total of $0.435 using two capsules, excluding enzymes for fats and sugars.
  • Company C: A total of $0.828 using three capsules for all food groups.

You can opt for a comprehensive product like Bio88+ or mix and match to avoid being tied to a single manufacturer. Ensure all chosen products adhere to high manufacturing standards and quality control.

Step 5: Identifying Additional Ingredients

Examine the product for non-enzyme components, such as:

  • Probiotics
  • Vitamins
  • Minerals aiding enzyme function (e.g., calcium ascorbate)
  • Amino acids
  • Herbs and whole foods
  • Potential allergens or intolerances
  • Ionic minerals, which may enhance enzyme activity

Step 6: Researching the Product and Manufacturer

Conduct thorough research on the product and its manufacturer. Contact the company for detailed information and ask direct questions about their products compared to competitors. Seek out experiences and feedback from others who have used the products, paying attention to side effects and interactions.

Step 7: Understanding Enzyme Names and Activities

Enzymes typically end with ‘ase’, indicating their function. For example, protease breaks down proteins, while lipase targets fats. Enzyme blends from microbial sources often contain a variety of enzymes, certified for specific activities. Proprietary blends may have unique names, making it challenging to determine exact activities.

Optimal Enzyme Blends

While it may seem beneficial to include numerous proteases, a blend of three or four may be as effective as smaller amounts of six or seven different proteases.

For further information on enzyme products, consider visiting reputable sources such as Organic Greens CA.


This guide is intended for informational purposes only and should not be construed as medical advice. Always consult with healthcare professionals before starting any new supplement regimen. The author and referenced materials are not responsible for the outcomes of decisions based on this information.


  • “Enzymes for Autism and other Neurological Conditions” – Book by Karen DeFelice
  • U.S. Pharmacopeia (USP) – Enzyme Standards
  • Food Chemical Codex (FCC) – Enzyme Activity Units

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Author: Piyawut Sutthiruk

Losing weight will keep you healthy and have a long life. Cheer Up!

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